Our team came through an exciting project about human skin medical animation. We aimed to create the ultrastructure of the dermis that changes the amount of collagen.

Human skin medical animation

General facts

The skin is the largest organ of the body. It comprises about 15% of the total adult body weight as the whole body is wrapped with it. As it is the principal site of interaction with the environment, it acts as a protective wall for internal tissues against pathogens, toxins, UV radiation and, furthermore, homeostasis. Moreover, the skin serves as a site for the synthesis of vitamin D, sensory perception. Our skin has good regenerative abilities and forms scar tissue when severely damaged. Skin is continuous with but structurally different from the mucous membranes lining the body’s surface. It consists of 3 coherent layers: the epidermis, the dermis, and the hypodermis.

Description of the video

This video is focused on the structure of the dermis, which is composed of two layers. First one is a thin superficial layer, made up of connective tissue that contains capillaries, elastic fibres, reticular fibres, and some collagen. The deeper reticular layer is more rough with the dense connective tissue and larger vessels that provide supply and waste removal from the basal layer of the epidermis and its cells. It has a more substantial amount of elastic fibres and stronger collagen fibre network. Besides, this layer is rich in mast cells, fibroblasts, nerve endings, lymphatic vessels, and epidermal appendages. The components mentioned above are surrounded by a gelatinous mix of chondroitin sulfates, hyaluronic acid,  and glycoproteins. The deeper dermis softly advances into hypodermis, so the margin is hardly recognizable.

What is collagen?

The primary component of the dermis is collagen, a fibrous family of proteins with at least 15 genetically distinct types in human skin. The video shows a schematic visualization of collagen secretion. Collagen fibres are a mesh of macromolecules built of many atoms to be a significant stress-resistant material for tissues. In the dermis, it holds fibroblasts in the net, which acts as a matrix where new cells can grow. Moreover, collagen works in replacing and restoring dead skin cells.

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