Nanobotmedical has created first nanorobot tetanus treatment animation of a conceptual bacteria-hunting nanorobot. The animation is about tetanus treatment.

About Clostridium tetani

The bacterium that causes tetanus (Clostridium tetani) is anaerobic, meaning it can thrive (i.e., infect) in an environment without oxygen. The concept of associating it with rust, especially rusty nails, is somewhat misleading. While objects that accumulate rust are usually found outdoors, or in places that contain anaerobic bacteria, the rust itself does not cause tetanus nor does it contain more C. tetani. The rough surface of the rusty metal which has endospores provides prime habitat for C. tetani. The nail punctures the skin deep enough to deliver endospores at the site of the wound.

Infection factors

C. tetani can remain infectious in the soil for more than 40 years in the spore form. You can get tetanus infection when the spores enter your body through an injury or wound. The spores release bacteria that spread in the body and release a neurotoxin called tetanospasmin (TeTx). This neurotoxin blocks nerve signals from your spinal cord to your muscles, causing severe muscle spasms. The prolonged muscular action causes sudden, powerful, and painful contractions of muscle groups, which is called tetany. These episodes can cause fractures and muscle tears. In about 1 of 10 cases, tetanus leads to death. Death can occur within four days.

Unlike many infectious diseases, recovery from tetanus does not confer immunity to tetanus. This is due to the extreme potency of the tetanospasmin; even a lethal dose of tetanospasmin is insufficient to provoke an immune response.

Project

NDA project 

Year of Creation

2013

What We Did

Video Production, Sound Production

Prevention

Tetanus can be prevented through immunization with tetanus-toxoid (TT) – containing vaccines.  The Centers for Disease Control and Prevention recommend that adults receive a booster dose every ten years [2]. Standard care practice in many places is to give the booster dose to any patient with a puncture wound who is uncertain of when he or she was last vaccinated. The booster dose may not prevent a potentially fatal case of tetanus from the current injury as it can take up to two weeks for tetanus antibodies to form.

Nanorobot tetanus treatment animation

Nanorobot concept

Nanobot Medical Animation Studio offers the vision of future treatment of tetanus and other toxic bacteria using medical nanorobots. Furthermore, this animation shows in detail a possible future treatment of tetanus. Nanomedicines’ concept of a next anti-bacterial artificial micro and nanomechanics offer a simple and straightforward idea. It depends on sophisticated medical nanomechanics of nanorobots. Maybe, these tiny artificial nanoelectromechanical systems will change 90% of traditional medical treatments, make them fast and more efficient.

Finally, the studio has created a groundbreaking artistic representation of a conceptual nanorobot tetanus treatment animation of bacteria-hunting nanorobot. This anti-tetanus nanorobot can destroy all C. tetani bacteria along with its spores in a matter of time.[3]. Moreover, it can denaturize the TeTx toxin that is responsible for muscular spasms and death. It can be done in several hours of physical treatment using nanorobots.

Mechanism of action

Most noteworthy, tetanus-killer nanorobot uses high temperature to destroy bacteria and its spores. Due to its small size, the nanorobot’ thermal treatment will be entirely local, and can’t harm living tissues. The surface of the nanobot will be covered by a bioconjugated polymer, which has high affinity to C.tetani surface protein markers. After deploying inside the bacteria, the nanorobot ejects cytoplasm heating cartridges. Inner thermal engine heats these cartridges [4]. In general, it can be a piezoelectric drive or even a distant infrared radiation source. Finally, the goal is to heat the nanobot up to 300F in seconds, that eliminates the C.tetani and TeTx toxin, both entirely. Moreover, this technology could be used in the treatment of various bacterial diseases. Furthermore, nanorobots with specific markers can “capture-and-destroy” bacteria species programmed by a physician.

[1] Hopkins, A.; Lahiri, T.; Salerno, R.; Heath, B. (1991). “Diphtheria, tetanus, and pertussis: recommendation for vaccine use and other preventive measures. Recommendations of the Immunization Practices Advisory committee (ACIP)”. MMWR Recomm Rep 40 (RR–10): 1–28. doi:10.1542/peds.2006-0692. PMID 1865873.

[2] CDC Features – Tetanus: Make Sure You and Your Child Are Fully Immunized. Retrieved 2010-08-30.

[3] Not an actual clinic treatment

[4] Robert A. Freitas Jr., Nanomedicine, Volume I: Basic Capabilities, Landes Bioscience, Georgetown, TX, 1999






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