Atherosclerosis is a widespread cardiovascular disease caused by accumulations of lipids, white blood cells, and other materials in the internal layer of arterial walls. In time atherosclerotic plaques calcification leading to the weakening of the arterial wall and a dramatic decrease of the vessel lumen. We created atherosclerosis plaque extraction scientific animation in order to display this changes and to show a possible in the future method of curing.

Calcification [1] occurs in vascular smooth muscle cells, specifically in the muscle cells adjacent to plaques. In time, as cells die, this leads to calcium deposits between the muscular wall and the atheromatous plaque.

Atherosclerosis plaque extraction scientific animation

Project

NDA project

Year of Creation

2016

What We Did

Video Production, Sound Production

Complications of advanced atherosclerosis are usually chronic, slowly progressive and cumulative. Most commonly, a soft plaque suddenly ruptures, causing the formation of a thrombus that will rapidly slow or obstruct blood flow, leading to the death of the tissues supplied by the artery. One of the most common recognized scenarios is thrombosis of a coronary artery. The same process in blood vessels of the brain is called a stroke.

Modern medicine use high-speed rotational atherectomy performed with an ablating grinder to remove the plaque has much better results in the treatment of calcified plaque compared to other methods [2].

However, the high-speed rotational atherectomy device produces micro-cavitation, which should be avoided because of the serious complications it can cause [2].

Future nanomedical devices can avoid this problem and also they can make atherectomy a non-invasive and more straightforward procedure.

Nanobot Medical Animation Studio created the first artistic representation of a conceptual atherosclerosis plaque removal by using medical nanorobots.

Medical nanorobots called “nano” because of the size of their components. These tiny artificial nanoelectromechanical systems will change 90% of traditional medical treatments, make them fast and more efficient.

Perhaps, the best mechanical nanocomputer is Drexler’s rod design. In this design, one sliding rod with a knob intersects a second knobbed sliding rod at a right angle to the first knob. Depending on the position of the first rod, the latter may be free to move, or unable to move. This simple blocking interaction serves as the basis for logical operations [3]. The same CPU logic can be used in anti-atherosclerosis nanorobot.

This nanorobot has magnetic markers – “cores” that can monitor its position inside the vascular system with high precision. That is why physicians can operate the nanorobot in real-time inside the bloodstream and control all movements of the nanorobot by a remote monitor (like MRI imaging). This device can remove a plaque without any invasive intervention or another complicated medical procedure.

[1] Bertazzo, S. et al. Nano-analytical electron microscopy reveal fundamental insights into human cardiovascular tissue calcification. Nature Materials 12, 576-583 (2013).

[2] Kim MH, Kim HJ, Kim NN, Yoon HS, Ahn SH. “A rotational ablation tool for calcified atherosclerotic plaque removal”, Biomed Microdevices. 2011 Dec;13(6):963-71. doi: 10.1007/s10544-011-9566-y.

[3] Robert A. Freitas Jr., Nanomedicine, Volume I: Basic Capabilities, Landes Bioscience, Georgetown, TX, 1999






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