Immune checkpoint 3D animation video

Reading time: 2 minutes

Immune checkpoint 3D animation video – to understand this complex mechanism, our team was supported by a scientific article published by Lu Sun et al.

Brief description of mechanism described in immune checkpoint 3D animation video

High complexity and specificity of the immune system require many rules and checkpoints to prevent autoimmunity and to “brake” immune response. One of them is shown in our immune checkpoint 3D animation video. Tumor cells show more changes in genetics and epigenetics than normal cells, which can theoretically produce sufficient amounts of antigens so that the immune system can distinguish them and trigger immune responses. However, immunosuppression makes it difficult to produce an effective immune response against tumor cells. These suppression signals are so-called immune checkpoints.

On the one hand, these suppression signals are involved in maintaining the immune tolerance of autoantigen, avoiding autoimmune diseases and injuries caused by excessive activation of an immune response. On the other hand, tumor cells can hide from immune recognition by suppressing the activation of T cell through immune checkpoints. Up till now, several molecular mechanisms of tumor cells’ escape from the immune recognition have been defined, such as tumor infiltrating macrophages which may limit activation and proliferation of T cell by interfering with amino-acid metabolism. Therefore, activating T cells through different strategies is the crucial focus of tumor immunotherapy, among which blockade of immune checkpoints is one of the most effective strategies.

What is PD-1 and why it is mentioned in immune checkpoint 3D animation video

PD-1 (programmed cell death protein-1) is a kind of important immunosuppressive transmembrane protein expressing on the surface of the T cells. PD-1 mainly restricts the activities of T cells in chronic inflammation, infection or cancer. It has two ligands, PD-L1 and PD-L2, which are related proteins found in antigen presenting cells and cancer cells. Tumor cells express PD-L1 or PD-L2, which can help tumor cells escape from the immune system by attaching to PD-1 protein on the surface of T cells. When ligands bind to PD-1, T cells cannot detect tumor cells, and the signal of attacking tumor cells will be blocked. Meanwhile, PD-1 reduces the threshold of apoptosis and induces energy of the immune system through the passivated T cell receptor signal, which usually leads to the depletion of the T cell.

If you like our immune checkpoint 3D animation video, don’t forget to share it with your friends!

Nanobot medical communication
"Everything was clear since day one for the communications and timelines."
Rosie Dawaliby, PhD
"They were always on time."
Anonymous
"They quickly understood what we needed and were very fast in delivering quality videos."
Maurice van Leeuwen
"I was impressed with their project management and the quality of their design."
Aude Boulitrop
"The team's quality of the deliverable was above expectations."
Anonymous
"They are professionals who are very good at what they do."
Sachith Gallolu
"They’re great; we don’t have to sit and wait for their work to be completed."
Anonymous
"Their clinical understanding was what made them stand out — their attention to detail was quite phenomenal."
Abhijith Ullas
"Their most impressive aspect is their artistic abilities."
Anonymous
"They were very easy to communicate with."
Anonymous
"We had engaged Nanobot previously on a medical animation project and we're very happy with the results."
Brynley Lee
"We were more impressed with their high level of creativity and creative design work."
Anonymous
"Their quick grasp of the underlying science and creativity in coming up with visual elements."
Hua Lin
"The team was always in contact and never changed."
Nathan Fox
"They have a great turnaround time."
Julie Kenner
"Workflow was seamless. Nanobot was ultra-responsive and completed the project in the desired time frame."
Larry Block
"They have a very efficient communication and workflow."
Joey Bose
"Their effectiveness and follow-up were impressive."
Dr. Gabriel Peter Salgo
"They produce quality work very quickly."
Alexander Pérez
"Their competitive pricing and rapid delivery were impressive."
Anonymous
"The quality of the animations is impressive!"
Anonymous
This website uses cookies and asks your personal data to enhance your browsing experience.